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[A case of mucosal Schwann cell hamartoma]
Shintaro Sagami1, Akira Fukumoto, Mio Amano
1Department of Gastroenterology, JA Onomichi General Hospital, Japan.
Insights
A rare case of mucosal Schwann cell hamartoma, a benign neurogenic tumor, was found in the sigmoid colon. This finding highlights the importance of investigating unusual colon findings.
Area of Science:
- Gastroenterology and Pathology
Background:
- Fecal occult blood tests can indicate underlying gastrointestinal pathology.
- Colonoscopy is crucial for visualizing and diagnosing colonic lesions.
Observation:
- A 40-year-old male presented with a positive fecal occult blood test.
- Colonoscopy identified multiple small, whitish nodules in the sigmoid colon mucosa.
- Endoscopic resection of nodules revealed spindle cell proliferation.
Findings:
- Immunohistochemistry showed strong S-100 protein positivity.
- Negative staining for neurofilament protein and epithelial membrane antigen.
- Diagnosis confirmed as mucosal Schwann cell hamartoma, a type of neurogenic tumor.
Implications:
- Mucosal Schwann cell hamartoma is a rare, benign entity.
- This case emphasizes the need for thorough histopathological examination of colonic lesions.
- Absence of features for multiple endocrine neoplasia type 2B or neurofibromatosis type 1 in this patient.
Abstract:
A 40-year-old man was referred to our hospital because of a positive fecal occult blood test. Colonoscopy revealed many small whitish nodules in the mucosa of the sigmoid colon. Specimens endoscopically resected from the lesions revealed spindle cell proliferation in the lamina propria. Immunohistochemical study revealed strong and diffuse positivity for S-100 protein. Results of staining for neurofilament protein and epithelial membrane antigen were negative. The neurogenic tumors were diagnosed as mucosal Schwann cell hamartoma. No clinical features of multiple endocrine neoplasia type 2B or neurofibromatosis type 1 were found in the present case.
