Related Experiment Video
Updated: May 17, 2026
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
A unique case of blastoid variant of mantle cell lymphoma with an aberrant CD5-/CD10+/Bcl-6+/CD56+ immunophenotype:
1Department of Pathology, Ewha Womans University School of Medicine, Seoul, Korea. americandoc@hanmail.net
Insights
CD56 expression is rare in B-cell lymphomas, with most cases being diffuse large B-cell lymphomas. This report details the first known case of CD56-positive mantle cell lymphoma (MCL), expanding knowledge of this rare presentation.
Area of Science:
- Immunology
- Hematology
- Oncology
Background:
- CD56, a neural adhesion molecule, is typically found on natural killer cells and T-cell subsets.
- Its expression is common in hematolymphoid neoplasms but rare in B-cell lymphomas.
- Most previously reported CD56-positive B-cell lymphomas were diffuse large B-cell lymphomas.
Observation:
- This case study focuses on a rare instance of CD56 expression in a B-cell lymphoma.
- The specific subtype examined was mantle cell lymphoma (MCL).
Findings:
- Mantle cell lymphoma (MCL) expressing CD56 has not been previously documented in scientific literature.
- This case represents the first reported instance of CD56 positivity in mantle cell lymphoma.
Implications:
- This finding expands the known spectrum of CD56 expression in lymphoid malignancies.
- It may prompt further investigation into the role of CD56 in the pathogenesis and diagnosis of mantle cell lymphoma.
- Understanding CD56 expression in MCL could potentially influence diagnostic criteria or therapeutic strategies.
Abstract:
The neural adhesion molecule CD56 is normally expressed on natural killer cells and subsets of T cells and is commonly found in hematolymphoid neoplasms. Expression of CD56 is very rare in B-cell lymphoma and most reported CD56-positive cases were diffuse large B-cell lymphomas. Cases of CD56-positive mantle cell lymphoma (MCL) have not previously been described in the literature. We present a case of CD56-positive MCL. To the best of our knowledge, this is the first case report of MCL expressing CD56.
