Related Experiment Video

Updated: May 16, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Conjunctival mass as an initial presentation of mantle cell lymphoma: a case report

Mahsa Khanlari1, Babak Bagheri, Reza Vojdani

  • 1Institute of Hematopathology, Dr Daneshbod Pathology Laboratory, Shiraz, Iran.

BMC Research Notes
|December 6, 2012
PubMed

Insights

This study details a rare case of mantle cell lymphoma (MCL) affecting the conjunctiva. Accurate diagnosis requires specific immunohistochemistry and genetic testing to distinguish it from other lymphomas.

Area of Science:

  • Ophthalmology
  • Hematology
  • Oncology

Background:

  • Mantle cell lymphoma (MCL) is a rare B-cell neoplasm.
  • Ocular adnexal lymphomas are typically extranodal marginal zone B-cell lymphomas (MALT).
  • Ocular MCL is an uncommon presentation requiring specific diagnostic considerations.

Observation:

  • A 64-year-old male presented with a three-month history of a right conjunctival mass.
  • Histopathology revealed a subconjunctival proliferation of small-to-medium-sized lymphoid cells with cleaved nuclei.
  • Immunohistochemistry confirmed the lymphoid infiltrate as positive for CD20, CD5, BCL-2, cyclin D1, and SOX11.

Findings:

  • Fluorescent in situ hybridization identified the IGH-CCND1 fusion, indicative of the t(11;14) translocation.
  • The findings confirm a diagnosis of mantle cell lymphoma in the conjunctiva.
  • This presentation highlights a rare ocular manifestation of MCL.

Implications:

  • Accurate diagnosis of ocular adnexal lymphomas is crucial.
  • Immunohistochemical and genetic analysis are essential for identifying ocular MCL.
  • Distinguishing ocular MCL from more common lymphomas ensures appropriate patient management and staging.
Abstract

More Related Videos

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma08:31

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

Published on: September 12, 2025

Related Concept Videos

Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...