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Ioversol for intravenous urography: a comparison study

A J Kaufman1, R Concepcion, F K Kirchner

  • 1Department of Radiology & Radiological Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2675.

Urologic Radiology
|January 1, 1990
PubMed

Insights

Ioversol and iohexol, both low-osmolar, nonionic contrast media, demonstrated equivalent safety and image quality in intravenous urography. Adverse effects were mild and comparable between the two agents, indicating they are interchangeable for this procedure.

Area of Science:

  • Radiology
  • Medical Imaging
  • Pharmacology

Background:

  • Nonionic, low-osmolar iodinated contrast media are preferred for intravenous urography.
  • Ioversol is a newer agent compared to iohexol.

Purpose of the Study:

  • To compare the safety, tolerance, and image quality of ioversol and iohexol.
  • To evaluate adverse effects and patient-reported symptoms during intravenous urography.

Main Methods:

  • A double-blind study involving 80 patients undergoing intravenous urography.
  • Patients were randomized into two groups (40 each) receiving either ioversol or iohexol.
  • Assessment included vital signs, patient tolerance (heat, pain), adverse events, and urogram image quality.

Main Results:

  • No severe or life-threatening reactions occurred in either group.
  • Mild adverse effects like perceived body heat, nausea, unpleasant taste, and headache were reported at similar rates for both ioversol and iohexol.
  • Vital signs remained stable, and urogram image quality was equivalent between the two contrast agents.

Conclusions:

  • Ioversol and iohexol are equivalent in terms of safety, adverse effect profile, and diagnostic image quality for intravenous urography.
  • Both agents are well-tolerated, with only mild, transient side effects observed.
  • The findings support the interchangeable use of ioversol and iohexol in clinical practice.

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