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Updated: May 9, 2026

Isolation of Primary Murine Retinal Ganglion Cells (RGCs) by Flow Cytometry
11:01

Isolation of Primary Murine Retinal Ganglion Cells (RGCs) by Flow Cytometry

Published on: July 5, 2017

Ganglion cell like cells, diagnostic dilemma

Anand Shankar Ammanagi1, Panduranga Chikkannaiah, Veerabhadrappa Veerappa Yenni

  • 1Department of Pathology, S.N. Medical College, Bagalkot, Karnataka, India.

Indian Journal of Dermatology
|August 7, 2013
PubMed

Insights

A rare cutaneous swelling initially diagnosed as ganglioneuroma was reclassified as fibromatosis. This highlights the need for immunohistochemistry beyond H and E staining for accurate diagnosis of skin lesions.

Area of Science:

  • Dermatopathology
  • Oncology
  • Surgical Pathology

Background:

  • Ganglioneuromas are rare, benign tumors typically found along sympathetic ganglia or in the adrenal medulla.
  • Primary cutaneous ganglioneuromas are exceptionally rare.
  • Cutaneous swellings can present diagnostic challenges.

Purpose of the Study:

  • To report a rare case of a cutaneous swelling initially diagnosed as ganglioneuroma.
  • To investigate the histological and immunohistochemical features of the lesion.
  • To emphasize the importance of advanced diagnostic techniques for cutaneous lesions.

Main Methods:

  • Histopathological examination using Hematoxylin and Eosin (H and E) staining.
  • Immunohistochemical analysis to determine cellular origin.
  • Gross examination of the excised dermal specimen.

Main Results:

  • The excised nodule showed spindle cells with ganglion cell-like features on H and E staining, initially suggesting ganglioneuroma.
  • Immunohistochemistry revealed a fibroblastic origin.
  • The final diagnosis was fibromatosis with ganglion cell-like fibroblasts.

Conclusions:

  • The histological features of ganglioneuromas can be mimicked by other cutaneous lesions.
  • Diagnosis solely based on H and E staining can be misleading for cutaneous ganglioneuromas.
  • Immunohistochemistry is crucial for accurate diagnosis of such rare skin tumors.

Keywords:
Fibromatosisganglionganglioneuromaskin

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