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Extra-nodal primary diffuse large B-cell lymphoma of the maxilla. Fine needle aspiration cytology
Alexandra Kalogeraki1, Dimitrios Tamiolakis, Ilias Ligoxygkakis
1Department of Pathology-Cytology, Medical Faculty, University of Crete, PO Box1393, Heraklion, 71110 Crete Greece. kalogerakimed@yahoo.gr.
Insights
Fine needle aspiration cytology (FNAC) aids in diagnosing diffuse large B-cell lymphoma in the maxilla. This method, combined with immunocytochemistry, effectively distinguishes between benign and malignant lymphoid infiltrates.
Area of Science:
- Oncology
- Pathology
- Hematology
Background:
- Extra-nodal lymphomas can present as masses in various anatomical sites.
- Maxillary masses require accurate diagnosis to differentiate benign from malignant conditions.
Purpose of the Study:
- To evaluate the utility of fine needle aspiration cytology (FNAC) in diagnosing diffuse large B-cell lymphoma (DLBCL) of the maxilla.
- To highlight the role of immunocytochemistry in conjunction with FNAC for accurate lymphoid infiltrate characterization.
Main Methods:
- A case study of a 76-year-old female with a large maxillary mass.
- Cytologic analysis of FNAB smears.
- Histological confirmation of the diagnosis.
- Immunocytochemistry for lymphoid marker analysis.
Main Results:
- FNAC smears revealed a cytologic diagnosis consistent with diffuse large B-cell lymphoma.
- Histological examination confirmed the diagnosis of maxillary DLBCL.
- Immunocytochemistry successfully differentiated malignant lymphoid infiltrates.
Conclusions:
- FNAC is a valuable tool for the initial diagnosis of maxillary masses.
- The combination of FNAC and immunocytochemistry is effective in diagnosing extra-nodal diffuse large B-cell lymphoma.
- This diagnostic approach supports prompt and accurate patient management.
Abstract:
A 76-year-old female presented at University hospital of Crete with a large painless mass (d<10 cm) of the left maxilla. The cytologic diagnosis in FNAB smears was of a diffuse large B-cell lymphoma of the maxilla that was confirmed histologically. The fine needle aspiration cytology (FNAC) in conjunction with immunocytochemistry can distinguish between benign and malignant lymphoid infiltrates and support a diagnosis of extra-nodal diffuse large B-cell lymphoma.