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A case of plasmablastic lymphoma diagnosed on liquid-based pap test
Julian Arce1, Kameelah Broadway, Jonathan Somma
1Department of Pathology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York.
Insights
This case report details a rare plasmablastic lymphoma in a 61-year-old woman with HIV presenting with vaginal bleeding. Diagnosis was challenging using the Pap test, highlighting the need for advanced techniques.
Area of Science:
- Gynecologic Oncology
- Hematology
- Pathology
Background:
- Primary gynecologic lymphomas are rare, often presenting with non-specific symptoms.
- Diagnosis can be challenging due to their rarity and subtle presentation on routine screening.
Observation:
- A 61-year-old female with human immunodeficiency virus (HIV) presented with vaginal bleeding.
- The case involved an uncommon plasmablastic lymphoma affecting the gynecologic tract.
Findings:
- Cytological features of plasmablastic lymphoma were identified on a liquid-based Pap test.
- Cell block studies and diagnostic immunohistochemistry were crucial for definitive diagnosis.
- The report discusses diagnostic difficulties associated with this rare malignancy.
Implications:
- This case underscores the importance of considering rare lymphomas in the differential diagnosis of gynecologic complaints, especially in immunocompromised patients.
- Advanced diagnostic methods beyond the Pap test are essential for early and accurate detection.
- Further literature review aids in understanding and managing such uncommon presentations.
Abstract:
Primary gynecological lymphomas are rare and difficult to diagnose with Pap test. Herein, we report an uncommon case of plasmablastic lymphoma in a 61-year-old female with human immunodeficiency virus that presents with vaginal bleeding. The following case report shows the cytological features on liquid-based Pap test, cell block studies with diagnostic immunohistochemistry, discussion of the diagnostic difficulties, and a literature review.
