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Primary cutaneous diffuse large B-cell lymphoma, leg type, with multiple local relapses: case presentation and brief

A Patsatsi1, A Kyriakou1, V Karavasilis2

  • 12 Dermatology Department.

Hippokratia
|December 31, 2013
PubMed

Insights

Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBL-LT) is an intermediate-behaving B-cell lymphoma primarily affecting elderly individuals. This case highlights PCDLBL-LT

Area of Science:

  • Dermatology
  • Oncology
  • Hematology

Background:

  • Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBL-LT) is a distinct subtype of non-Hodgkin lymphoma.
  • This lymphoma typically exhibits intermediate behavior and predominantly affects elderly patients.

Observation:

  • A 76-year-old male presented with characteristic red to violaceous nodules on the anterior aspects of both tibias.
  • Histopathological examination confirmed PCDLBL-LT. Systemic involvement was ruled out, but thoracic CT revealed mediastinal lymphadenopathy.

Findings:

  • The patient initially responded well to R-CHOP chemotherapy, achieving complete lesion clearance.
  • However, the patient experienced a relapse five months later, necessitating palliative radiotherapy, which was also used for a subsequent recurrence.

Implications:

  • PCDLBL-LT predominantly affects the elderly, often presenting with age-related comorbidities.
  • The tendency for frequent relapses in PCDLBL-LT underscores the critical need for stringent patient follow-up and tailored management strategies.

Keywords:
B-cell cutaneous lymphomaR-CHOP regimenleg type (PCDLBL-LT)primary cutaneous diffuse large B-cell lymphoma

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