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In-depth conversation: spectrum and kinetics of neuroimmune afferent pathways

Ning Quan1

  • 1Institute for Behavior Medicine Research, The Ohio State University, Columbus, OH 43210, USA.

Brain, Behavior, and Immunity
|February 26, 2014
PubMed

Insights

Neuroimmune communication, the interaction between the nervous and immune systems, has grown significantly. This review integrates findings into a framework for understanding healthy and dysfunctional neuroimmune interactions.

Area of Science:

  • Neuroimmunology
  • Neuroscience
  • Immunology

Background:

  • The field of neuroimmune communication has expanded considerably since 2008.
  • New phenomena reveal intricate crosstalk between the nervous and immune systems.
  • Neuroimmune interactions are increasingly recognized in disease pathogenesis and physiological coordination.

Purpose of the Study:

  • To integrate diverse findings on neuroimmune communication.
  • To present a modified conceptual framework for neuroimmune interactions.
  • To describe the concordance and potential dysfunction in neuroimmune crosstalk.

Main Methods:

  • Literature review and synthesis of recent research.
  • Integration of basic science and translational findings.
  • Development of a conceptual framework for neuroimmune communication.

Main Results:

  • Substantial growth in understanding neuroimmune phenomena.
  • Evidence for neuroimmune interactions in disease and health.
  • Recognition of the dynamic nature of neuroimmune communication.

Conclusions:

  • A modified framework is proposed to understand neuroimmune communication.
  • Cooperative connections are key in healthy neuroimmune function.
  • Inappropriate crosstalk can lead to dysfunction.

Keywords:
CytokinesNeuroimmune communicationNeuroinflammation

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