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Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes
Published on: December 20, 2014
Role of centrosome in regulating immune response
Ambuj Kumar, Vidya Rajendran, Rao Sethumadhavan
1Bioinformatics Division, School of Bio Sciences and Technology, Vellore Institute of Technology University, Vellore 632014, Tamil Nadu, India. riturajpurohit@gmail.com.
Insights
Centrosomes are crucial for cell cycle and immune responses, directing secretory granules to the immunological synapse. Their precise molecular mechanisms in immune cell function require further investigation.
Area of Science:
- Cell Biology
- Immunology
Background:
- Centrosomes are key regulators of the cell cycle.
- Emerging evidence highlights their role in modulating immune responses.
Purpose of the Study:
- To review the importance of centrosomes in immune signaling.
- To elucidate the role of centrosome polarization in immune cell function.
Main Methods:
- Literature review of recent investigations on centrosome function in immunity.
- Analysis of centrosome polarization in cytotoxic T lymphocytes and other immune cells.
Main Results:
- Centrosome polarization is essential for delivering secretory granules to the immunological synapse (IS).
- This mechanism is utilized by cytotoxic cells of both innate and adaptive immunity.
Conclusions:
- Centrosomes play a vital role in immune cell-mediated cytotoxicity and immune signaling.
- Further research is needed to fully understand the molecular mechanisms and cellular functions of centrosomes in immunity.
Abstract:
Centrosomes are the vital component of cell cycle progression pathway. Recent investigations have suggested their role in regulating the immune response system. Centrosome polarization delivers secretory granules to the immunological synapse (IS). The Cytotoxic T lymphocytes use a specific mechanism, controlled by centrosome delivery to the plasma membrane for delivering the secretory granules to the immunological synapse. Moreover, the polarization of centrioles to the immunological synapse directs secretion from cytolytic cells of innate as well as adaptive immune systems. Although the recent investigations have suggested their strong role in mediating the crucial events of immunological response, there are few discrepancies that are yet to be resolved. Furthermore, a clear picture of their molecular mechanism along with their cellular functions has not been reported. In this manuscript we have reviewed some important points that explain the importance of centrosomes in mediating the immunological signals and the delivery of lytic discharge from the cytotoxic and killer cells.
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