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[Effect of immunomodulatory therapy on circulatory immune complexes in patients with recurrent depressive disorders]
Insights
Cycloferon, an immunomodulatory therapy, positively impacts immunological parameters in depression patients. It helps normalize circulatory immune complexes (CIC) and their fractions, aiding in treatment.
Area of Science:
- Immunology
- Psychiatry
- Pharmacology
Context:
- Recurrent depressive disorders are associated with altered immunological parameters.
- Elevated levels of circulatory immune complexes (CIC) are observed in depression patients.
- The pathogenic role of CIC fractions in disease severity requires further investigation.
Purpose:
- To evaluate the effect of cycloferon, an immunomodulatory agent, on immunological parameters in patients with depression.
- To assess the impact of cycloferon on circulatory immune complexes (CIC) and their molecular fractions.
- To determine if cycloferon enhances standard antidepressant and antipsychotic treatments.
Summary:
- A study involving 192 patients with recurrent depressive disorders investigated the efficacy of cycloferon as an add-on therapy.
- Patients receiving standard treatment plus cycloferon showed a normalization of CIC levels and their fractions compared to the control group.
- A direct correlation was observed between depression severity and the degree of change in immunological parameters.
Impact:
- The findings suggest that cycloferon can positively modulate immunological disturbances associated with depression.
- Inclusion of cycloferon in treatment regimens may lead to improved immunological profiles in patients with depressive disorders.
- This study highlights the potential of immunomodulatory therapies in managing complex psychiatric conditions.
Objectives:
To study an effect of immunomodulatory therapy with cycloferon on some immunological parameters in patients with depression.
Materials And Methods:
It was examined 192 patients with recurrent depressive disorders. All patients were randomized into two groups -- main group (98 patients) and comparison group (94 patients). Both groups received standard treatment with antidepressants and antipsychotics in ambulatory conditions. Patients of the main group additionally received cycloferon.
Results:
Before treatment, there was an increase in concentrations of circulatory immune complexes (CIC), mainly due to most pathogenic average molecular (11S-19S) and small molecular (<11S) fractions, in both groups of the patients. A direct correlation between the degree of the severity of the disease and the degree of changes in immunological parameters was noted.
Conclusions:
Inclusion of cycloferon in the complex treatment had a positive effect on immunological parameters and led to the normalization of CIC levels and their fraction content.
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