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The role of the microenvironment in human immunodeficiency virus-associated classical Hodgkin lymphoma

Athanasios Koulis1, Pritesh Trivedi, Hazem Ibrahim

  • 1Imperial College, Department of Histopathology, Hammersmith Hospital Campus, London, UK.

Histopathology
|May 10, 2014
PubMed

Insights

Classical Hodgkin lymphoma (cHL) in people living with HIV (PLWH) shows distinct immune cell profiles. Researchers observed significant differences in T cells, B cells, and other immune cells in the cHL microenvironment of PLWH.

Area of Science:

  • Immunology
  • Oncology
  • Virology

Background:

  • Classical Hodgkin lymphoma (cHL) is a malignancy of lymphocytes.
  • The tumor microenvironment plays a critical role in cancer progression and immune evasion.
  • Human immunodeficiency virus (HIV) infection alters immune system function, potentially impacting cHL development and characteristics.

Purpose of the Study:

  • To characterize and quantify the immune cell populations within the tumor microenvironment of cHL in people living with HIV (PLWH).
  • To compare the immune microenvironment of cHL in PLWH with that in individuals without HIV.

Main Methods:

  • Tissue microarray technology and immunohistochemistry were employed.
  • Ten cHL samples from PLWH were analyzed and compared to ten cHL samples from the general population.
  • Immunostaining was performed using antibodies for CD30, CD3, CD4, CD8, CD20, CD68R, CD56, CD57, CD123, FoxP3, and granzyme B.

Main Results:

  • A statistically significant reduction in CD4(+) T cells, CD56(+) cells, CD57(+) cells, CD123(+) cells, and B cells was observed in cHL from PLWH.
  • An increase in FoxP3(+) CD8(+) cells was noted in cHL diagnosed in PLWH.
  • No significant differences were found in CD8(+) T cells, CD4(+) FoxP3(+) T cells, and macrophages between the two groups.

Conclusions:

  • The tumor microenvironment of cHL differs considerably between individuals with and without HIV.
  • These findings highlight unique immunological aspects of cHL in the context of HIV infection.
Abstract

Keywords:
classical Hodgkin lymphomahuman immunodeficiency virushuman immunodeficiency virus-associated classical Hodgkin lymphomaimmune system cellsinflammationtumour microenvironment

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