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The intercellular cell adhesion molecule-1 (icam-1) in lung cancer: implications for disease progression and

Elias A Kotteas1, Panagiotis Boulas1, Ioannis Gkiozos1

  • 1Oncology Unit GPP, Athens School of Medicine, Sotiria General Hospital, Athens, Greece.

Anticancer Research
|September 10, 2014
PubMed

Insights

Intercellular cell-adhesion molecule-1 (ICAM-1) plays a role in cell interactions and is linked to inflammation and cancer. This study explores ICAM-1

Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Background:

  • Intercellular cell-adhesion molecule-1 (ICAM-1) is a transmembrane protein in the Immunoglobulin superfamily.
  • ICAM-1 is crucial for leukocyte transmigration, cell signaling, and tissue stability.
  • Elevated ICAM-1 levels are observed in inflammatory conditions, chronic diseases, and malignancies.

Purpose of the Study:

  • To investigate the role and implications of ICAM-1 in lung cancer progression.
  • To analyze the impact of ICAM-1 on the prognosis of lung cancer patients.

Main Methods:

  • Review of existing literature on ICAM-1.
  • Analysis of ICAM-1 expression in relation to lung cancer development.
  • Correlation of soluble ICAM-1 levels with patient outcomes.

Main Results:

  • ICAM-1 is implicated in the complex processes driving lung cancer.
  • Soluble ICAM-1 expression correlates with disease progression and patient prognosis in lung cancer.

Conclusions:

  • ICAM-1 is a significant factor in lung cancer progression and prognosis.
  • Targeting ICAM-1 may offer potential therapeutic strategies for lung cancer.

Keywords:
Intercellular cell-adhesion moleculecell polaritycell signalingcell-cell interactionimmunoglobulinlung cancerprognosisreview

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