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[The indicators of immune status of peripheral blood of donors]
Insights
Analysis of blood donors revealed immune system disorders in some individuals. A frequent abnormality observed was a decrease in natural killer cells, indicating potential health issues among seemingly healthy donors.
Area of Science:
- Immunology
- Hematology
Context:
- Analysis of peripheral blood samples from 57 conditionally healthy individuals.
- Samples were collected from the blood storage department of a hematology research institute.
Purpose:
- To analyze lymphocyte populations, activated cell pools, and cytokine levels in conditionally healthy blood donors.
- To identify immune system aberrations in individuals presenting as healthy donors.
Summary:
- Standard immune parameters like T-lymphocytes, T-helpers, and activated T-cells (CD3+HLA-R+) showed no significant deviation from established data.
- However, variations were noted, including increased cytolytic T-lymphocytes, B-lymphocytes, and natural killer cells, alongside altered CD4/CD8 ratios.
- The most common aberration identified was a decrease in natural killer cell counts.
Impact:
- Highlights the presence of individuals with immune system disorders within the 'conditionally healthy' blood donor population.
- Suggests the need for enhanced immune screening of blood donors to ensure blood safety and identify potential health concerns.
Abstract:
The expanded analysis of 57 samples of peripheral blood from conditionally healthy patients was implemented concerning phenotype of main populations of lymphocytes, activated pools of cells and level of cytokines. The samples were received in the department of storage of blood and its components of the research institute of blood transfusion of the hematology research center. It is demonstrated that number of T-lymphocytes, T-helpers and activated TY-cells with phenotype CD3+HLA-R+ and level of detected cytokines by standard indicators had no difference with publications data. In particular cases an increase of number of cytolytic T-lymphocytes, B-lymphocytes and natural killers and decrease or increase of CD4/CD8 index relative to standard were detected. The decrease of number of natural killers was the most frequent aberration. The study demonstrates that among conditionally healthy patients giving blood as donors persons with disorders of immune system were presented.
