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Overview of automated immunohistochemistry

Jeffrey W Prichard1

  • 1From the Department of Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania.

Archives of Pathology & Laboratory Medicine
|November 27, 2014
PubMed

Insights

Automated immunohistochemistry platforms offer solutions for clinical diagnostics amid staff shortages. Understanding platform differences is key to optimizing testing volume, turnaround time, and labor savings in histology labs.

Area of Science:

  • Histopathology
  • Clinical Diagnostics
  • Laboratory Automation

Background:

  • Increasing demand for immunohistochemistry (IHC) in clinical diagnostics.
  • Shortage of skilled staff in histology laboratories necessitates automation.
  • Current automated IHC platforms exhibit diverse designs and capabilities.

Purpose of the Study:

  • To review technological applications in automating immunohistochemical staining.
  • To analyze the evolution and impact of automated IHC staining.

Main Methods:

  • Comprehensive literature review of automated IHC technologies.
  • Interviews with vendors of automated staining platforms.
  • Analysis of personal practical experience with IHC instrumentation.

Main Results:

  • Commercially available automated IHC platforms possess distinct strategic design features.
  • Each platform presents unique advantages and disadvantages in workflow integration.
  • Variability exists in automation capabilities impacting standardization and efficiency.

Conclusions:

  • Understanding design differences in automated IHC platforms is crucial.
  • Matching platform capabilities to specific laboratory demands (volume, turnaround time, labor) is essential for optimal utilization.
  • Strategic selection of automated instrumentation can enhance diagnostic efficiency and consistency.
Abstract

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