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Urinary podocyte can be an indicator for the pathogenetic condition of patients with IgA nephropathy

Peicheng Shen, Jiaojiao Shen, Wenwen Li

    Clinical Laboratory
    |February 6, 2015
    PubMed

    Insights

    Detecting urinary podocytes offers a noninvasive method to assess IgA nephropathy severity. Elevated urinary podocyte counts correlate with worse clinical and pathological outcomes in IgA nephropathy patients.

    Area of Science:

    • Nephrology
    • Immunology
    • Pathology

    Background:

    • IgA nephropathy (IgAN) is a primary glomerular disease.
    • Podocyturia, the presence of podocytes in urine, may indicate podocyte injury.

    Purpose of the Study:

    • To evaluate the clinical significance of urinary podocytes in IgA nephropathy patients.
    • To establish urinary podocyte detection as a noninvasive biomarker for IgAN severity.

    Main Methods:

    • Collected urine samples from 102 biopsy-confirmed IgA nephropathy patients.
    • Detected urinary podocytes using indirect immunofluorescence staining with anti-human Podocalyxin (PCX) antibody.
    • Correlated urinary podocyte counts with clinicopathological changes.

    Main Results:

    • Patients with positive urinary podocytes showed reduced plasma albumin and glomerular filtration rate, and increased urinary protein, cholesterol, and mean arterial pressure.
    • Positive urinary podocyte group had fewer glomerular podocytes, more mesangial matrix, interstitial fibrosis, and foot process fusion.
    • Urinary podocyte counts correlated positively with serum creatinine and 24-hour urinary protein, and negatively with glomerular podocyte number.

    Conclusions:

    • Urinary podocyte detection is a valuable noninvasive indicator.
    • This method reflects the severity of IgA nephropathy.
    • Urinary podocytes can aid in monitoring disease progression and treatment response.
    Abstract

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