Related Experiment Video

Updated: Apr 17, 2026

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
08:31

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

Published on: September 12, 2025

1.0K

Indolent lymphoma: follicular lymphoma and the microenvironment-insights from the microscope

Nancy Lee Harris1

  • 1Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Hematology. American Society of Hematology. Education Program
|February 20, 2015
PubMed

Insights

Follicular lymphomas (FLs) are cancers of germinal center (GC) B cells. Their microenvironment, composed of non-neoplastic cells, influences tumor survival and is studied using microscopy and gene expression profiling.

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Follicular lymphomas (FLs) originate from germinal center (GC) B cells, mirroring normal GC B cell characteristics.
  • The tumor microenvironment, comprising non-neoplastic cells, significantly impacts FL biology and B cell survival.
  • Understanding the GC/FL microenvironment is crucial for comprehending FL pathogenesis.

Purpose of the Study:

  • To review insights into the follicular lymphoma microenvironment derived from morphological and immunophenotypic analyses.
  • To discuss the role of gene expression profiling in understanding the GC/FL microenvironment.
  • To highlight challenges in enumerating microenvironmental cells for clinical prognostication.

Main Methods:

  • Morphological analysis of neoplastic follicles.
  • Immunophenotypic characterization of cellular components.
  • Gene expression profiling of GC/FL tissues.

Main Results:

  • GC B cells and FL cells share numerous features with normal GC B cells.
  • The microenvironment contains non-neoplastic cells that interact with FL B cells.
  • Microscopic and gene expression studies have advanced understanding of the microenvironment.

Conclusions:

  • The microenvironment plays a vital role in follicular lymphoma survival.
  • Morphological and immunophenotypic analyses provide key insights into the GC/FL microenvironment.
  • Clinical prognostication based on microenvironment cell enumeration faces significant challenges.

More Related Videos

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.8K
Isolation of Murine Lymph Node Stromal Cells05:47

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

32.6K

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.2K
The Tumor Microenvironment02:17

The Tumor Microenvironment

3.2K
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
10.6K
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
4.0K
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
17.0K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
10.3K