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Updated: Apr 16, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
Diagnostic difficulties in acute myeloid leukemia
Insights
This case study highlights diagnostic challenges in acute myeloid leukemia (AML). Morphological discrepancies across samples led to a final AML diagnosis after comprehensive analysis.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Accurate diagnosis of acute myeloid leukemia (AML) is critical for effective treatment.
- Morphological assessment of blood and bone marrow is a cornerstone of leukemia diagnosis.
- Immunophenotyping plays a vital role in classifying myeloid and lymphoid malignancies.
Abstract:
We present the case of a patient who presented cells with different morphologic appearance, lymphoblasts on peripheral blood smear, lymphoblasts on bone marrow aspirate and myloblasts on bone marrow biopsy, and immunophenotyping, leading to different stage diagnosis. The final diagnosis was that of acute myeloid leukemia (LAM0).
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