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Updated: Apr 16, 2026

Employing Digital Droplet PCR to Detect BRAF V600E Mutations in Formalin-fixed Paraffin-embedded Reference Standard Cell Lines
10:16

Employing Digital Droplet PCR to Detect BRAF V600E Mutations in Formalin-fixed Paraffin-embedded Reference Standard Cell Lines

Published on: October 8, 2015

13.8K

Evidence of BRAF V600E in indeterminate cell tumor and interdigitating dendritic cell sarcoma

Dennis P O'Malley1, Renuka Agrawal2, Kate E Grimm2

  • 1Clarient Pathology Services, Aliso Viejo, CA; MD Anderson Cancer Center, University of Texas, Houston, TX.

Annals of Diagnostic Pathology
|March 20, 2015
PubMed

Insights

BRAF V600E mutations are found in rare histiocytic and dendritic cell neoplasms. This study highlights their association with lymphomas, suggesting a potential link and expanding the known spectrum of these tumors.

Area of Science:

  • Oncology
  • Pathology
  • Genetics

Background:

  • BRAF V600E mutations are implicated in various histiocytic and dendritic cell neoplasms.
  • Understanding the co-occurrence of these mutations with lymphoid malignancies is crucial.

Observation:

  • This case series reviewed BRAF V600E-positive histiocytic and dendritic cell neoplasms.
  • Immunohistochemistry was used to confirm BRAF V600E status and categorize tumors.

Findings:

  • The study identified BRAF V600E-positive indeterminate cell tumor associated with angioimmunoblastic T-cell lymphoma.
  • A BRAF V600E-positive interdigitating dendritic cell sarcoma was observed in a patient with a positive B-cell polymerase chain reaction.

Implications:

  • The findings expand the spectrum of BRAF V600E-positive histiocytic and dendritic cell tumors.
  • The potential transdifferentiation from lymphoid neoplasms or independent development requires further investigation.
  • Clinicians should consider screening lymphomas for coincident BRAF V600E-positive histiocytic and dendritic cell neoplasms.

Keywords:
BRAF V600EIndeterminate cell tumorInterdigitating dendritic cell sarcomaLangerhans cell histiocytosis

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