Related Experiment Video
Updated: Apr 14, 2026
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
[CD20-positive plasma cell myeloma with lymphoplasmacytoid appearance mimicking low-grade B-cell lymphoma]
Shojiro Haji1, Yasunobu Abe, Mariko Tsuda
1Division of Hematology, National Kyushu Cancer Center, National Hospital Organization.
Insights
Differentiating CD20 positive myeloma with lymphoplasmacytoid morphology from lymphoma is challenging. This case highlights myeloma with t(11;14) translocation presenting with these features, responding well to lenalidomide.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- CD20 positive myeloma can mimic mature B-cell lymphoma due to lymphoplasmacytoid morphology.
- Accurate differentiation is crucial for appropriate diagnosis and treatment.
Abstract:
CD 20 positive myeloma with small lymphoplasmacytoid morphology is difficult to differentiate from mature B-cell lymphoma. A 71-year-old male was referred to our hospital because of osteolytic vertebral fractures and anemia. Urine was positive for Bence Jones protein, κ type. Bone marrow consisted of approximately 30% small lymphoplasmacytoid cells with scant cytoplasm, and these cells were positive for CD20, CD23 and CD138. FISH analysis revealed t(11;14)(CCND1/IGH). Myeloma with t(11;14) is closely associated with small lymphoplasmacytoid appearance and CD20 and CD23 expressions. The patient was diagnosed as having myeloma based on clinical and cytogenetic findings, and achieved VGPR (very good partial response) after treatment with lenalidomide.
