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Polyclonal B cell activation in paracoccidioidomycosis. Polyclonal activation in paracoccidioidomycosis

D Chequer-Bou-Habib1, C Daniel-Ribeiro, D M Banic

  • 1Departamento de Imunologia, WHO Collaborating Centre for Research and Training in the Immunology of Parasitic Diseases, Rio de Janeiro, Brazil.

Mycopathologia
|November 1, 1989
PubMed

Insights

Paracoccidioidomycosis (PCM) involves polyclonal B lymphocyte activation (PBA). Researchers found significantly elevated IgG secreting cells and increased immunoglobulin levels in PCM patients, indicating active B cell stimulation.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Medical Mycology

Background:

  • Paracoccidioidomycosis (PCM) is frequently linked to elevated immunoglobulin levels and circulating immune complexes.
  • The underlying mechanisms driving these immunological alterations in PCM are not fully understood.

Purpose of the Study:

  • To investigate the presence and extent of polyclonal B lymphocyte activation (PBA) in patients with Paracoccidioidomycosis.
  • To correlate B lymphocyte activation markers with clinical and immunological findings in PCM.

Main Methods:

  • Quantification of IgG secreting cells (IgG SC) in peripheral blood from 16 PCM patients and 8 healthy controls.
  • Measurement of serum immunoglobulin (IgG, IgA) levels and circulating immune complexes (CIC).

Main Results:

  • PCM patients exhibited significantly higher numbers of peripheral blood IgG SC compared to healthy controls.
  • Elevated serum levels of IgG, IgA, and CIC were observed in PCM patients.
  • These findings suggest ongoing B lymphocyte activation in active PCM.

Conclusions:

  • Polyclonal B lymphocyte activation (PBA) is an active process during Paracoccidioidomycosis (PCM).
  • The study provides evidence for B cell hyperactivity contributing to the hypergammaglobulinemia and immune complex formation seen in PCM.

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