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Updated: Apr 12, 2026
Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
Published on: May 10, 2022
[Recent Advances of Researches on Expression, Function and Regulation of CD22]
Xiao-Jing Wu1, Zong-Hong Shao1
1Department of Hematology, General Hospital of Tianjin Medical University, Tianjin 300052, China.
Insights
CD22, a B lymphocyte protein, regulates B-cell receptor signaling. Its dysfunction is linked to autoimmune diseases, highlighting its potential as a therapeutic target.
Area of Science:
- Immunology
- Cell Biology
- Biochemistry
Context:
- CD22 is a type I transmembrane protein crucial for B lymphocyte function.
- It acts as a co-receptor for the B-cell receptor (BCR), modulating BCR signaling pathways.
Purpose:
- To review the structure, expression, ligands, and regulatory functions of CD22.
- To explore the role of CD22 in B cell signaling and its implication in autoimmune diseases.
Summary:
- CD22 phosphorylation, triggered by antigen-receptor interaction, leads to the dephosphorylation and inactivation of downstream proteins, inhibiting BCR signaling.
- Abnormal CD22 expression or function disrupts BCR signaling, affecting B cell quantity and function, potentially causing autoimmune diseases.
Impact:
- Understanding CD22's role is vital for elucidating autoimmune disease pathogenesis.
- Further research on CD22 could establish a theoretical basis for targeted autoimmune disease treatments.
Abstract:
CD22 is a type I transmembrane protein expressed on most mature B lymphocyte, and plays a significant role in signal transduction pathways. CD22 acts as a co-receptor of the B-cell receptor (BCR) that inhibits the BCR signaling by antigen-receptor interaction. The phosphorylation of CD22 can be triggered by cross-linking of CD22 with the BCR through antigen, then predominantly triggers the dephosphorylation and inactivation of downstream proteins and inhibit the BCR signaling. Autoimmune disease could be caused by the abnormal expression or dysfunction of CD22 which interrupts BCR signaling and then influences the quantity and function of B cells. The further study of the function and regulation of CD22 would help us understanding the pathogenesis of autoimmune disease and setting theoretical basis for its targeting treatment. In this article, the structure and expression of CD22, the ligands of CD22, the regulation of BCR and transmenbrane signaling, the effect of CD22 on B cells, and CD22 and autoimmune diseases were reviewed.
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