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Homotopic reciprocal functional connectivity between anterior human insulae

Nuria Lacuey1, Bilal Zonjy2, Emine S Kahriman2

  • 1Epilepsy Center, UH Case Medical Center, 11100 Euclid Avenue, Cleveland, OH, 44106, USA. nuria.lacuey@uhhospitals.org.

Brain Structure & Function
|May 22, 2015
PubMed

Insights

This study explored brain connectivity between the right and left insulae. Researchers found evidence of direct, rapid communication pathways between these crucial brain regions.

Area of Science:

  • Neuroscience
  • Human Brain Imaging
  • Functional Connectivity

Background:

  • The insula plays a vital role in various cognitive and emotional processes.
  • Understanding inter-insular connectivity is crucial for mapping brain networks.
  • Previous research has not fully elucidated the direct functional links between the right and left insulae.

Purpose of the Study:

  • To investigate the functional connectivity between the right and left insulae in the human brain.
  • To determine the nature and latency of evoked responses between contralateral insular structures.

Main Methods:

  • Utilized stereotactically placed depth electrodes in both insulae of a single patient undergoing epilepsy surgery evaluation.
  • Applied bipolar 1 Hz electrical stimulation to the posterior short gyri of the anterior insula.
  • Recorded evoked responses in contralateral insular structures.

Main Results:

  • Electrical stimulation of one insula evoked responses in the contralateral insula.
  • Evoked responses exhibited a short latency of 8-24 milliseconds.
  • Demonstrated bi-directional homotopic and heterotopic functional connectivity between the right and left anterior insulae.

Conclusions:

  • Established the first evidence of direct, bi-directional functional connectivity between the right and left anterior insulae.
  • The short latency suggests mono- or oligo-synaptic connections, likely involving the corpus callosum.
  • This finding advances our understanding of interhemispheric brain communication via the insular cortex.

Keywords:
CCEPCorpus callosumEpilepsyEvoked potentialsFunctional connectivityInsula

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