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DC-SIGN: The Strange Case of Dr. Jekyll and Mr. Hyde

Juan J Garcia-Vallejo1, Yvette van Kooyk1

  • 1Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam MF-B242, 1081BT, the Netherlands.

Immunity
|June 18, 2015
PubMed

Insights

Costimulatory blockade promotes regulatory T cell (Treg) expansion by increasing CD209a(+) macrophages. These macrophages interact with fucosylated ligands, enhancing Treg cell numbers for immune balance.

Area of Science:

  • Immunology
  • Cellular Biology

Background:

  • Regulatory T cells (Treg) are crucial for immune homeostasis.
  • Understanding Treg cell expansion mechanisms is vital for immune modulation.

Purpose of the Study:

  • To investigate how costimulatory blockade influences Treg cell populations.
  • To identify cellular interactions promoting Treg cell expansion.

Main Methods:

  • Utilized costimulatory blockade in an experimental model.
  • Analyzed macrophage populations, specifically CD209a(+) macrophages.
  • Investigated interactions between macrophages and fucosylated ligands.
  • Quantified CD4(+)Foxp3(+) Treg cell numbers.

Main Results:

  • Costimulatory blockade led to an accumulation of CD209a(+) macrophages.
  • CD209a(+) macrophages interacted with fucosylated tissue ligands.
  • This interaction promoted a significant expansion of CD4(+)Foxp3(+) Treg cells.

Conclusions:

  • Costimulatory blockade is a viable strategy to enhance Treg cell numbers.
  • CD209a(+) macrophages and fucosylated ligands play a key role in Treg cell expansion.
  • Findings offer insights into immune tolerance and autoimmune disease therapies.

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