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Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
08:53

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma

Published on: June 10, 2017

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Reed-Sternberg-Like Cells in Non-Hodgkin Lymphomas

Juan C Gomez-Gelvez1, Lauren B Smith

  • 1From the Department of Pathology, University of Michigan Medical School, Ann Arbor.

Archives of Pathology & Laboratory Medicine
|September 29, 2015
PubMed

Insights

Pathologists must distinguish large atypical cells resembling Reed-Sternberg cells in lymph node biopsies. Recognizing these cells in reactive lymphadenopathies and lymphomas prevents diagnostic pitfalls.

Area of Science:

  • Hematopathology
  • Surgical Pathology
  • Immunophenotyping

Background:

  • Large atypical cells mimicking Reed-Sternberg cells occur in reactive lymphadenopathies and lymphomas.
  • These cells present a significant diagnostic challenge for pathologists interpreting lymph node biopsies.

Purpose of the Study:

  • To review lymphomas presenting with Reed-Sternberg-like cells.
  • To detail morphologic and immunophenotypic features of these cells.
  • To provide strategies for differentiating them from classical Hodgkin lymphoma.

Main Methods:

  • Review of literature and case examples.
  • Morphologic analysis of atypical cells in lymph node biopsies.
  • Immunophenotypic characterization of Reed-Sternberg-like cells.

Main Results:

  • Reed-Sternberg-like cells are observed in various lymphomas and reactive conditions.
  • Distinct morphologic and immunophenotypic profiles aid in differentiation.
  • Contextual analysis of the cellular environment is critical.

Conclusions:

  • Accurate identification of Reed-Sternberg-like cells is crucial for correct lymphoma diagnosis.
  • Comprehensive evaluation of morphology, immunophenotype, and cellular milieu is essential.
  • Distinguishing these cells from classical Hodgkin lymphoma requires careful pathological assessment.

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