[CD4⁺/CD8⁻ T- cell large granular lymphocytic leukemia: one case report and literatures reviews]
Yang Li1, Zhijie Wu1, Jianping Li1
1Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.
Insights
This case study details a rare CD4+/CD8- T-cell large granular lymphocytic leukemia variant. Understanding its distinct clinical features is crucial for accurate diagnosis and patient management.
Area of Science:
- Hematology
- Immunology
- Oncology
Background:
- T-cell large granular lymphocytic leukemia (T-LGL) is a rare clonal proliferation of cytotoxic T-lymphocytes.
- Classic T-LGL typically exhibits a CD4-/CD8+ immunophenotype.
- Variant subtypes, such as CD4+/CD8- T-LGL, present unique clinical and biological characteristics.
Objective:
Presenting the clinical features of one patient with CD4⁺/CD8⁻ T-cell large granular lymphocytic leukemia, to improve the understanding of the disease.
Methods:
Clinical data of one patient hospitalized for skin rush and leukocytosis were analyzed, and the related literatures were reviewed.
Results:
The patient was hospitalized for skin rush and leukocytosis. Routine blood test showed remarkable elevated white blood cell counts and mild anemia. Subsequent hematological examination led to a diagnosis of T- cell large granular lymphocytic leukemia with CD4⁺/CD8⁻ immunophenontype.
Conclusion:
CD3⁺/CD4⁺/CD8⁻ T- cell large granular lymphocytic leukemia is a kind of variant subtype, and is relatively rare, it has different clinical features with classic CD3⁺/CD4⁻/CD8⁺/TCRαβ⁺T- cell large granular lymphocytic leukemia, so differentiating diagnosis is of great importance.
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