[ANTIPLATELET THERAPY INFLUENCE ON IMMUNOLOGICAL STATUS OF PROGRESSIVE ANGINA PATIENTS]

Area of Science:

• Cardiology
• Immunology

Background:

• Progressive angina (PA) is a serious cardiovascular condition.
• Understanding the impact of antiplatelet therapy on immune status in PA patients is crucial.

Purpose of the Study:

• To evaluate the efficacy of clopidogrel with aspirin versus clopidogrel alone in treating PA patients.
• To assess the effects of these treatments on specific immune markers.

Main Methods:

• Monoclonal antibodies were used to determine lymphocyte populations and subpopulations.
• The Mancini method was employed to measure serum levels of Immunoglobulin G, A, M, and circulating immune complexes (CIC).
• The study included 65 PA patients aged 67-73 years.

Main Results:

• The combination of clopidogrel and aspirin demonstrated a positive trend in multiple immune status indicators.
• This combination therapy was found to be more effective than clopidogrel monotherapy in the basic treatment of PA patients.
• Improvements were observed in lymphocyte profiles and immune complex levels.

Conclusions:

• Combination therapy with clopidogrel and aspirin is a more effective treatment strategy for progressive angina patients.
• This approach positively influences the immune status of elderly PA patients.
• Further research into immune modulation by antiplatelet agents is warranted.