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Primary cutaneous lymphomas: A clinical and histological study of 99 cases in Isfahan, Iran
Farahnaz Fatemi Naeini1, Bahareh Abtahi-Naeini1, Mohsen Pourazizi2
1Department of Dermatology, Skin diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Insights
This study found primary cutaneous lymphomas (PCLs) in Iran lack male predominance and occur at a younger age compared to global data. These findings highlight regional variations in PCL epidemiology.
Area of Science:
- Dermatology
- Oncology
- Epidemiology
Background:
- Primary cutaneous lymphomas (PCLs) are a diverse group of skin-confined T- and B-cell malignancies.
- Understanding PCL epidemiology is crucial for diagnosis and treatment.
- This study focuses on PCL characteristics in Isfahan, Iran.
Purpose of the Study:
- To determine the epidemiological features of PCLs in Isfahan, Iran.
- To compare these characteristics with global PCL data.
- To identify potential ethnic or regional variations.
Main Methods:
- Retrospective analysis of 99 PCL patients diagnosed between 2003-2013.
- Classification based on WHO-EORTC criteria.
- Statistical analysis using means, standard deviations, and significance testing (P < 0.05).
Main Results:
- The cohort included 45 men and 54 women, with a median age of 36 years.
- Mycosis fungoides (MFs) was the most common subtype (86.9%), followed by Sézary syndrome (SS) (4%).
- A notable finding was the absence of male predominance and a shorter latency period in women.
Conclusions:
- PCLs in Iran exhibit distinct epidemiological traits, including a lower age of onset and no male predominance.
- These findings underscore the importance of considering regional and ethnic variations in PCL presentation.
- Further research is needed to explore these variations.
Background:
Primary cutaneous lymphomas (PCLs) represent a heterogeneous group of T- and B-cell lymphomas that present in the skin with no evidence of extracutaneous disease at the time of diagnosis. The aim of this study was to assess and report the epidemiological characteristics of PCLs in Isfahan, Isfahan Province, Iran - as a main province of Iran.
Materials And Methods:
A total of 99 patients were recruited over a recent 10-year period (2003-2013) with diagnosis of PCLs; the patients were classified according to the The World Health Organization/European Organization for Research and Treatment of Cancer (WHO-EORTC) criteria. Mean and standard deviations (SDs) were used to describe continuous data, numbers, and percentages for categorical data. Statistical significance was defined as P < 0.05.
Results:
The patients comprised 45 men and 54 women aged 5-80 years (median 36) at diagnosis. The male-to-female ratio was 1:1.2. Histological examination showed features of primary cutaneous B-cell lymphomas (PCBCLs) in four cases. The mean ± SD age in primary cutaneous T-cell lymphomas (PCTCLs) and PCBCLs was 37.9 ± 16.5 years and 39.7 ± 9.1 years, respectively (P = 0.72). The mean ± SD latent period between the time of diagnosis and initiation of skin lesions in men and women was 2.3 ± 4.1 years and 5.9 ± 10.1 years, respectively (P = 0.02). The most frequent subtypes were mycosis fungoides (MFs) (86.9%) followed by Sιzary syndrome (SS) (4%). Five patients died from PCL-related deaths.
Conclusion:
The distinguishing epidemiologic characteristics of PCL in Iran are the absence of a male predominance and a lower age of diagnosis. The study highlights the ethnic or regional variations in the clinicoepidemiological characteristics of PCLs.
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