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Updated: Mar 26, 2026

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
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An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

Published on: April 18, 2016

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Histiocytic and Dendritic Cell Neoplasms

Dan Jones1

  • 1Quest Diagnostics Nichols Institute, 14207 Newbrook Drive, Chantilly, VA 20153, USA.

Surgical Pathology Clinics
|February 4, 2016
PubMed

Insights

This review covers dendritic cell (DC) tumors, including myeloid sarcoma and Langerhans cell neoplasms. It highlights their diverse features and origins, emphasizing precursor cell plasticity in these cancers.

Area of Science:

  • Pathology
  • Hematology
  • Oncology

Background:

  • Dendritic cells (DCs) are crucial immune cells with diverse subtypes, including myeloid-derived, plasmacytoid, and follicle-associated.
  • Tumors arising from these DCs and related myeloid precursors present complex diagnostic challenges.

Purpose of the Study:

  • To review the morphologic and immunophenotypic features of dendritic cell tumors and related neoplasms.
  • To discuss the classification and diagnostic considerations for these rare malignancies.

Main Methods:

  • Review of existing literature and case studies on dendritic cell neoplasms.
  • Analysis of morphologic and immunophenotypic characteristics of various tumor types.
  • Discussion of histogenetic relationships and precursor cell plasticity.

Main Results:

  • Mature neoplasms include Langerhans cell histiocytosis and its sarcoma, and S100-negative histiocytic proliferations.
  • Immature/precursor malignancies encompass myeloid/monocytic leukemias and blastic plasmacytoid dendritic cell neoplasm.
  • Mesenchymal-type lymph node tumors, such as follicular dendritic cell sarcomas, are also discussed despite potential differences in origin.

Conclusions:

  • Dendritic cell neoplasms exhibit a wide spectrum of features due to the plasticity of their non-neoplastic precursors.
  • Accurate diagnosis requires careful integration of morphology, immunophenotype, and consideration of potential histogenetic origins.

Keywords:
Dendritic cellsLineage infidelityLymph node sarcomasPlasticityTransdifferentiation

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