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Uveal lymphoid infiltrates: immunohistochemical evidence for a lymphoid neoplasia

D Ben-Ezra1, J A Sahel, N L Harris

  • 1Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel.

The British Journal of Ophthalmology
|October 1, 1989
PubMed

Insights

A rare diffuse uveal melanoma was initially suspected in a patient, but was later diagnosed as a low-grade B cell lymphoma. This highlights the diagnostic challenges of uveal lymphoid infiltrates.

Area of Science:

  • Ophthalmology
  • Oncology
  • Pathology

Background:

  • Uveal lymphoid infiltrates can mimic other ocular conditions, posing diagnostic challenges.
  • Distinguishing between benign lymphoid infiltrates and malignant uveal melanoma is critical for patient management.

Observation:

  • A 67-year-old male presented with clinical and ultrasonographic findings suggestive of diffuse uveal melanoma.
  • Histopathological and immunohistochemical analysis post-enucleation revealed a diffuse, low-grade B cell lymphoma or lymphoplasmacytic immunocytoma.

Findings:

  • The case underscores the difficulties in the clinical and histopathological differential diagnosis of uveal lymphoid infiltrates.
  • Morphological and immunohistochemical data were crucial in reclassifying the initial suspicion of uveal melanoma.

Implications:

  • Accurate diagnosis of uveal lymphoid infiltrates is essential due to the favorable prognosis of lymphomas.
  • Treatment strategies should prioritize ocular function preservation for patients with these conditions.

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