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Polarity and asymmetric cell division in the control of lymphocyte fate decisions and function

Mohammed Yassin1, Sarah M Russell2

  • 1Immune Signalling Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Australia; Centre for Micro-Photonics, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Hawthorn, Australia; Department of Pathology, The University of Melbourne, Australia.

Current Opinion in Immunology
|March 6, 2016
PubMed

Insights

Lymphocyte asymmetric cell division (ACD) is crucial for immune responses. New methods quantify ACD during lymphocyte development, clarifying its role in cell fate decisions.

Area of Science:

  • Immunology
  • Cell Biology
  • Developmental Biology

Background:

  • Cell polarity is vital for lymphocyte functions like migration and immunological synapse formation.
  • The specific role of asymmetric cell division (ACD) in lymphocytes remains less understood compared to other polarity-related processes.

Purpose of the Study:

  • To investigate the significance of lymphocyte asymmetric cell division (ACD).
  • To leverage recent advancements in polarity measurement for a clearer understanding of ACD in lymphocytes.

Main Methods:

  • Utilizing novel techniques for precise measurement of cell polarity.
  • Quantifying asymmetric cell division (ACD) during specific lymphocyte developmental and activation stages.

Main Results:

  • Recent advancements have enabled robust quantification of ACD in lymphocytes.
  • Crucial data on ACD has been obtained at precise phases of lymphocyte development and activation.

Conclusions:

  • New methods for measuring polarity are enhancing the study of lymphocyte ACD.
  • These developments improve our understanding of how ACD influences cell fate choices during lymphocyte activation.

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