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Updated: Mar 19, 2026

Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper cTfh Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry
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Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper cTfh Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry

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Composite Follicular Lymphoma and CD5-Positive Nodal Marginal Zone Lymphoma

Masashi Miyaoka1, Tomoki Kikuchi, Joaquim Carreras

  • 1Department of Pathology, Tokai University School of Medicine.

Journal of Clinical and Experimental Hematopathology : JCEH
|June 24, 2016
PubMed

Insights

This study details an extremely rare composite lymphoma case, combining follicular lymphoma (FL) and CD5-positive nodal marginal zone lymphoma (NMZL). It

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Composite lymphomas, particularly those involving low-grade B-cell neoplasms, are exceptionally uncommon in clinical practice.
  • Accurate diagnosis and classification are crucial for appropriate patient management and treatment strategies in hematologic malignancies.

Observation:

  • A rare case of composite follicular lymphoma (FL) and CD5-positive nodal marginal zone lymphoma (NMZL) was identified in a 72-year-old Japanese male's inguinal lymph node.
  • Histopathological examination revealed distinct areas consistent with both FL (CD10-positive) and CD5-positive NMZL (monocytoid B-cells).

Findings:

  • Immunohistochemical analysis confirmed the presence of CD10-positive B-cells within germinal centers (FL component) and CD5-positive B-cells in the marginal zones (NMZL component).
  • Molecular analysis of the immunoglobulin heavy chain gene demonstrated distinct CDR3 sequences, supporting the clonal origin of both lymphoma subtypes within the same lymph node.

Implications:

  • This case represents the first documented instance of a composite FL and CD5-positive NMZL, expanding the spectrum of rare B-cell lymphomas.
  • Understanding such rare composite lymphomas is vital for refining diagnostic criteria and potentially guiding future therapeutic approaches in hematologic oncology.

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