Related Experiment Video
Updated: Mar 15, 2026
Refined Murine Model of Idiopathic Pulmonary Fibrosis
Published on: June 17, 2025
Solitary pulmonary MALT lymphoma presenting crystal-storing histiocytosis
Keiki Nagaharu1, Yuki Kageyama, Takuya Watanabe
1Department of Hematology and Oncology, Suzuka General Hospital.
Insights
Crystal-storing histiocytosis (CSH) can manifest as an initial sign of blood cancers. This case highlights a patient diagnosed with CSH and lymphoma, who remained disease-free after surgery.
Area of Science:
- Oncology
- Pathology
Background:
- Crystal-storing histiocytosis (CSH) is a rare disorder characterized by immunoglobulin crystal deposition within histiocytes.
- CSH is frequently associated with hematological malignancies, necessitating thorough investigation for underlying blood disorders.
Observation:
- A 69-year-old male with a history of renal pelvic cancer presented with a progressing pulmonary nodule.
- The patient underwent pulmonary lobectomy, leading to a diagnosis of CSH concurrent with mucosa-associated lymphoid tissue lymphoma (MALT lymphoma).
Findings:
- The patient was diagnosed with CSH and stage IAE MALT lymphoma.
- Following surgical resection, the patient experienced no recurrence of disease for 10 months without further treatment.
Implications:
- CSH can serve as an early indicator of hematological malignancies.
- Close monitoring and evaluation for associated blood disorders are crucial in patients diagnosed with CSH.
Abstract:
Crystal-storing histiocytosis (CSH) is characterized by the accumulation of large histiocytes with intracytoplasmic crystallized immunoglobulin and is typically associated with hematological malignancies. A 69-year-old man, who had a history of left nephrectomy and chemotherapy for renal pelvic cancer six years earlier, had received a CT scan every year thereafter and a small nodule was found in the left lower lobe of his lungs two years prior to the current presentation. Because of progression of this pulmonary nodule, he underwent pulmonary lobectomy on suspicion of lung cancer. He was ultimately diagnosed as having CSH accompanied by mucosa-associated lymphoid tissue lymphoma stage IAE. In the absence of further treatment, he has been well with no recurrence of the disease for 10 months postoperatively. Because CSH could reportedly be an initial presentation of hematological malignancies, careful observation and evaluation for the presence of these blood disorders is essential.
