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Updated: Aug 8, 2026
An Orthotopic Bladder Cancer Model for Gene Delivery Studies
Published on: December 2, 2013
Squamous cell carcinoma of bladder after successful intravesical therapy with Bacillus Calmette-Guérin
D W Brenner1, L M Yore, P F Schellhammer
1Department of Urology, Eastern Virginia Medical School, Norfolk.
Insights
A rare case of invasive squamous cell carcinoma of the bladder developed after Bacillus Calmette-Guérin (BCG) immunotherapy in a patient with existing bladder squamous dysplasia. This highlights a potential, though uncommon, complication of BCG treatment.
Area of Science:
- Uro-oncology
- Immunotherapy research
- Cancer pathology
Background:
- Intravesical Bacillus Calmette-Guérin (BCG) is a standard treatment for non-muscle invasive bladder cancer.
- Squamous dysplasia of the bladder is a premalignant condition.
- The development of invasive squamous cell carcinoma following BCG therapy is uncommon.
Abstract:
A case of invasive squamous cell carcinoma of the bladder following intravesical immunotherapy with Bacillus Calmette-Guérin in a patient with pre-existing squamous dysplasia of the bladder is presented.
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