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Composite Blastoid Variant of Mantle Cell Lymphoma and Classical Hodgkin Lymphoma

Ciara Murray1, Fiona Quinn1, Gyorgy Illyes2

  • 11 St James's Hospital, Dublin, Ireland.

International Journal of Surgical Pathology
|November 10, 2016
PubMed

Insights

This case report details a rare composite lymphoma involving blastoid mantle cell lymphoma and classical Hodgkin lymphoma. It is the first documented instance of this specific combination, highlighting diagnostic challenges.

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Composite lymphoma (CL) is defined as the simultaneous presence of two or more distinct lymphoma subtypes in one anatomical site.
  • Malignancies involving lymphoid tissues require precise classification for effective treatment strategies.

Observation:

  • A 78-year-old male presented with constitutional symptoms including weakness, malaise, and dyspnea.
  • Neck lymph node biopsy revealed two distinct lymphoid neoplasms: blastoid variant of mantle cell lymphoma (MCL) and classical Hodgkin lymphoma (cHL), mixed cellularity subtype.

Findings:

  • Fluorescence in situ hybridization confirmed a t(11;14)(q13;q32) translocation in both MCL and Hodgkin Reed-Sternberg cells.
  • Molecular analysis demonstrated clonal immunoglobulin gene rearrangements in the MCL component.
  • This represents the first reported case of composite blastoid MCL and cHL.

Implications:

  • This case underscores the importance of thorough clinicopathological and molecular evaluation in diagnosing rare composite lymphomas.
  • Understanding the coexistence of distinct lymphoma subtypes is crucial for accurate prognostication and therapeutic decisions.
  • Further research into the pathogenesis and behavior of composite lymphomas may improve patient outcomes.

Keywords:
Hodgkin lymphomablastoid variantcomposite lymphomamantle cell lymphoma

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