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Improvement of Intestinal Immune Cell Function by Lactic Acid Bacteria for Dairy Products

Tomonori Kamiya1, Yohei Watanabe2, Seiya Makino3

  • 1Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8566, Japan. t-kamiya@aist.go.jp.

Microorganisms
|December 28, 2016
PubMed

Insights

This study shows that specific lactic acid bacteria (LAB) strains, Lactobacillus bulgaricus ME-552 and Streptococcus thermophilus ME-553, can enhance immune responses. These probiotics modulate T cell function and mucosal immunity.

Area of Science:

  • Microbiology
  • Immunology
  • Gastroenterology

Background:

  • Lactic acid bacteria (LAB) are key gut microbiota components and common probiotic supplements.
  • LAB are utilized in fermented foods like yogurt, influencing host health.

Purpose of the Study:

  • To assess the immunomodulatory effects of specific LAB strains, Lactobacillus bulgaricus ME-552 (ME552) and Streptococcus thermophilus ME-553 (ME553).
  • To investigate the impact of these LAB on T cell function using in vivo and in vitro assays.

Main Methods:

  • Oral administration of ME553 to C57BL/6 mice.
  • Analysis of cytokine production (interferon-gamma and interleukin-17) by cluster of differentiation 4-positive (CD4+) T cells from Peyer's patches (PPs).

Main Results:

  • ME553 significantly increased both interferon-gamma (IFN-γ) and interleukin-17 (IL-17) production by CD4+ T cells in Peyer's patches.
  • ME552 primarily upregulated IL-17 production from Peyer's patch cells.
  • Differential effects of ME552 and ME553 on IFN-γ induction were observed.

Conclusions:

  • LAB strains possess immunomodulatory activities.
  • These specific LAB can enhance T cell effector functions and influence mucosal immunity.

Keywords:
Dendritic cellsInterferon γInterleukin 17Lactic acid bacteriaLactobacillus bulgaricusMucosal immunityPeyer’s patchesProbioticsStreptococcus thermophilusT helper cells

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