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[CT findings of inflammatory myofibroblastic tumor of different pathological types]
1First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
Insights
Computed tomography (CT) features of inflammatory myofibroblastic tumor (IMT) vary by pathological type. CT aids in assessing IMT extent and relation to adjacent organs, guiding treatment decisions.
Area of Science:
- Radiology
- Pathology
- Oncology
Background:
- Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm with diverse clinical presentations.
- Accurate diagnosis and staging are crucial for effective management.
Purpose of the Study:
- To investigate the computed tomography (CT) characteristics of IMT across different pathological subtypes.
- To enhance the diagnostic accuracy of IMT using imaging findings.
Main Methods:
- Retrospective analysis of CT features in 29 pathologically confirmed IMT cases.
- Correlation of imaging findings with pathological classifications (mucinous blood vessel, spindle cell, fiber types).
- Statistical analysis (Chi-Square test) of patient demographics and CT features.
Main Results:
- IMTs occurred in a wide age range (2-78 years).
- Immunohistochemical markers showed variable expression (Vimentin+, SMA+, ALK±, CD-67±, S-100-).
- Statistically significant differences in gender distribution were observed among pathological types.
Conclusions:
- CT and clinical features of IMT are associated with its pathological type.
- Diagnosis requires integration of CT findings with pathology and immunohistochemistry.
- CT is valuable for evaluating IMT extension and its relationship with adjacent structures, informing treatment planning.
Abstract:
Objective: To explore the computed tomography(CT) features of inflammatory myofibroblastic tumor(IMT) in different pathological types, and improve the diagnostic level of this disease. Methods: The CT features of 29 cases pathologically confirmed IMTs were retrospectively reviewed along with a literature review to analyze the CT features and pathological correlations, and three kinds of pathological classification of IMT in patients with gender , shape, boundary and location were respectively analyzed by Chi-Square test. Results: The age ranges from 2 to 78 years.There were 7 cases of mucinous blood vessel type and 13 cases of spindle cell type and 9 cases of fiber type.Immunohistochemically, Vimentin (22/29) and SMA (28/29) were positive in all the cases, ALK (4/29) and CD-67(6/29) were partly positive expression, other markers such as S-100 were negative expression.The Chi-Square test showed that there were statistically differences in the gender of the patients. Conclusion: The CT and clinical features differ according to pathological types of IMT. Its final diagnosis still needs to be combined with pathology and immunohistochemistry result. In all, CT has a role in assessing the extension of IMT and especially about the relationship with adjacent organs which can effectively direct the establishment of clinical treating scheme.
