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Okt6 Positme Epidermal L4ngerhans Cells in Tinea Corporis

R B Narayanan, A Girdhar, R K Lavania

    Indian Journal of Dermatology, Venereology and Leprology
    |January 31, 2017
    PubMed

    Insights

    Tinea corporis lesions show significantly reduced Langerhans cells (LC) compared to normal skin. This decrease in epidermal LC may contribute to the weakened cell-mediated immunity observed in fungal skin infections.

    Area of Science:

    • Dermatology
    • Immunology
    • Mycology

    Background:

    • Tinea corporis is a superficial fungal infection of the skin.
    • Langerhans cells (LC) are critical immune cells in the epidermis, playing a role in initiating immune responses.
    • The role of LC in the pathogenesis of tinea corporis is not fully understood.

    Purpose of the Study:

    • To investigate the number and distribution of Langerhans cells in the skin lesions of patients with untreated tinea corporis.
    • To assess the potential correlation between LC reduction and cell-mediated immunity (CMI) in this condition.

    Main Methods:

    • Indirect immunofluorescence was used to identify and quantify Langerhans cells.
    • The OKT6 monoclonal antibody was employed to detect LC in skin biopsy specimens.
    • Comparison was made between LC in lesional skin and normal skin.

    Main Results:

    • A significant reduction in the number and distribution of epidermal LC (T6+ cells) was observed in tinea corporis lesions compared to normal skin.
    • In most lesions, epidermal LC were undetectable.
    • Antigens associated with LC were not found on keratinocytes.

    Conclusions:

    • The findings suggest a diminished cell-mediated immune response to fungal infection in tinea corporis.
    • A reduction in Langerhans cells may be a contributing factor to the altered immune response and pathogenesis of tinea corporis.

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