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Composite Diffuse Large B-cell and Mantle Cell Lymphoma: A Case Report

Farhan Mohammad1, Gwenalyn Garcia1, Shiksha Kedia1

  • 1Department of Hematology and Oncology, Staten Island University Hospital.

Cureus
|February 14, 2017
PubMed

Insights

This study reports a rare case of composite lymphoma, a condition with two distinct lymphoma subtypes in one lymph node. The patient had diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) that were clonally unrelated.

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Composite lymphoma, an exceptionally rare condition, involves the coexistence of two distinct lymphoma subtypes within a single lymph node.
  • This specific combination of diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) is exceedingly uncommon.

Observation:

  • A 57-year-old male presented with leg and groin pain, leading to a biopsy of the right inguinal lymph node.
  • Histopathological examination revealed a mixture of large and small cells.
  • Immunohistochemistry confirmed the presence of DLBCL (large cells) and MCL (small cells).

Findings:

  • Polymerase chain reaction (PCR) analysis demonstrated that the DLBCL and MCL components were clonally unrelated.
  • This represents the third reported case of composite lymphoma with this specific DLBCL and MCL combination in the English literature.

Implications:

  • This case highlights the diagnostic challenges associated with composite lymphoma.
  • Understanding the distinct clonal origins is crucial for accurate diagnosis and effective management strategies.
  • Further research into the pathogenesis and optimal treatment of such rare composite lymphomas is warranted.

Keywords:
compositelymphomar-chop

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