Related Experiment Video
Updated: Mar 7, 2026
Author Spotlight: Identification and Isolation of Quiescent Leukemia Stem Cells from Zebrafish T-ALL
Published on: July 19, 2024
Initial Lymphocyte Count as Prognostic Indicator for Childhood Immune Thrombocytopenia
Sinan Akbayram1, Kamuran Karaman1, Murat Dogan2
1Department of Pediatric Hematology, Yuzuncu Yil University, Van, Turkey.
Insights
Absolute lymphocyte counts at diagnosis can predict the development of chronic immune thrombocytopenia (ITP). Lower lymphocyte counts indicate a higher risk for developing chronic ITP.
Area of Science:
- Hematology
- Immunology
- Clinical Medicine
Background:
- Immune thrombocytopenia (ITP) is characterized by low platelet counts.
- Acute ITP is typically self-limiting, while chronic ITP persists beyond 12 months.
- Predictive markers for chronic ITP are crucial for patient management.
Purpose of the Study:
- To investigate the predictive value of absolute lymphocyte counts (ALC) at diagnosis for chronic ITP.
- To identify clinical factors associated with the progression of ITP to a chronic state.
Main Methods:
- Retrospective evaluation of 601 patients diagnosed with ITP between 1995 and 2014.
- Analysis of complete blood counts (CBCs) with differential counts at presentation.
- Statistical analysis to determine predictors of chronic ITP.
Main Results:
- 25.9% of patients developed chronic ITP.
- Age >6.75 years, platelet count >6,950/mm³, and ALC ≤2,050/mm³ were associated with increased risk.
- ALC at diagnosis independently predicted disease duration and the development of chronic ITP.
Conclusions:
- Absolute lymphocyte counts at diagnosis are significant predictors of chronic ITP.
- Further research is needed to confirm these findings and explore the pathophysiology.
- Identifying patients at risk for chronic ITP can aid in early intervention strategies.
Abstract:
Acute ITP is a benign, self-limiting disease. Chronic ITP is diagnosed when thrombocytopenia persists beyond 12 months. The main objective of the present study was to examine whether absolute lymphocyte counts at diagnosis has predictive value with chronic ITP. A total of 601 patients diagnosed as ITP between 1995 and 2014 were retrospectively evaluated. CBCs with differential counts were performed at presentation for 601 patients. Absolute lymphocyte counts at presentation were independently predictive of disease duration. The male to female ratio was almost 1:1 and 25.9 % (156/601) of the patients had chronic ITP. We determined that age >6.75 year, platelet counts >6.950/mm3 and absolute lymphocyte counts ≤2.050/mm3 was associated with a significant risk for developing chronic ITP. Absolute lymphocyte counts at the time of diagnosis were predictive variables for the development of chronic ITP. Further researches are needed to confirm the current finding and to assess the underlying pathophysiology with the course of the ITP in observational studies.
More Related Videos
08:31Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
07:40Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis
Published on: March 20, 2021
Related Concept Videos
01:27Disorders of Leukocytes
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
01:23Cells of the Adaptive Immune Response