Related Experiment Video

Updated: Aug 9, 2026

Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus
11:18

Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus

Published on: May 7, 2012

13.4K

Hepatitis C virus - Associated marginal zone lymphoma

Marine Armand1, Caroline Besson2, Olivier Hermine3

  • 1Department of Hematology, Hôpital Pitié-Salpêtrière, AP-HP, Paris, France; UPMC Univ Paris 06, UMRS-1138, Paris, France.

Best Practice & Research. Clinical Haematology
|March 15, 2017
PubMed

Insights

Hepatitis C virus (HCV) infection is linked to B-cell non-Hodgkin lymphoma, particularly marginal zone lymphoma (MZL) and diffuse large B-cell lymphoma (DLBCL). Antiviral treatment can lead to lymphoma regression, highlighting the virus's role in cancer development.

Area of Science:

  • Virology
  • Oncology
  • Immunology

Background:

  • The association between Hepatitis C Virus (HCV) infection and B-cell non-Hodgkin lymphoma (NHL) is well-established.
  • Epidemiological studies and observed lymphoma regression post-HCV eradication support this link.
  • Marginal Zone Lymphoma (MZL) and Diffuse Large B-cell Lymphoma (DLBCL) are the most frequently observed subtypes.

Purpose of the Study:

  • To elucidate the role of HCV in lymphomagenesis.
  • To explore proposed mechanisms linking HCV to lymphoma development.
  • To assess the efficacy of antiviral therapy in treating HCV-associated lymphomas.

Main Methods:

  • Review of epidemiological studies.
  • Observation of lymphoma regression following antiviral treatment.
  • Analysis of proposed pathogenetic mechanisms.

Main Results:

  • HCV infection is a significant risk factor for developing MZL and DLBCL.
  • Lymphoma regression is observed after successful HCV eradication.
  • Proposed mechanisms include chronic B-cell receptor stimulation and direct viral protein effects.

Conclusions:

  • Antiviral therapy, especially direct-acting antiviral agents, is effective and safe for treating HCV-associated MZL.
  • Understanding HCV's role in lymphomagenesis is crucial for targeted treatment strategies.
  • Further research into viral-host interactions can refine therapeutic approaches for HCV-related lymphomas.

Keywords:
Hepatitis C virusLymphomagenesisMarginal zone lymphomaTreatment

More Related Videos

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.7K
Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice07:25

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

7.5K

Related Concept Videos

Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...