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Published on: March 30, 2018
Urinary tract involvement of mantle cell lymphoma diagnosed by urine cytology
Diane Hamele-Bena1, Abel Arnoldo Gonzalez1
1Clinical Pathology & Cell Biology, New York Presbyterian Hospital, Columbia University Medical Center, 630 West 168th Street P&S 16-404, New York, New York, 10032.
Insights
Mantle cell lymphoma (MCL) rarely affects the urinary bladder. This study reports the first case of MCL in the urinary bladder diagnosed using urine cytology and immunocytochemistry.
Area of Science:
- Oncology
- Uropathology
- Cytopathology
Background:
- Urinary tract lymphoma is uncommon, typically involving the kidney.
- Urinary bladder lymphoma is exceptionally rare.
- Mantle cell lymphoma (MCL) is a less common subtype of non-Hodgkin lymphoma.
Observation:
- A rare case of Mantle cell lymphoma (MCL) involving the urinary bladder is presented.
- The diagnosis was established through urine cytology analysis.
- Immunocytochemical stains provided crucial confirmatory evidence.
Findings:
- Urine cytology can effectively diagnose urinary bladder Mantle cell lymphoma (MCL).
- Immunocytochemistry is essential for confirming MCL in urine samples.
- This represents the first reported case of MCL diagnosed via urine cytology.
Implications:
- This case expands the diagnostic utility of urine cytology in identifying rare hematolymphoid malignancies.
- It suggests urine cytology may be a valuable, non-invasive tool for detecting bladder lymphomas.
- Further research could explore the role of cytology in monitoring treatment response for such conditions.
Abstract:
Urinary tract lymphoma is unusual, with the kidney being the most commonly reported site of involvement. Urinary bladder involvement by lymphoma is rare. Mantle cell lymphoma (MCL) is a relatively uncommon type of lymphoma. Herein, we report a case of MCL of the urinary bladder diagnosed by urine cytology, with confirmatory immunocytochemical stains, which has not previously been reported in the literature.
