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Transient Central Diabetes Insipidus and Marked Hypernatremia following Cardiorespiratory Arrest

Sahar H Koubar1, Eliane Younes2

  • 1Department of Medicine, Division of Nephrology, American University of Beirut Medical Center and School of Medicine, Beirut, Lebanon.

Case Reports in Nephrology
|August 1, 2017
PubMed

Insights

Transient Central Diabetes Insipidus (CDI) can occur after cardiopulmonary arrest and brain injury. This case highlights how CDI can cause severe hypernatremia, worsened by fluid management.

Area of Science:

  • Neurology
  • Endocrinology
  • Critical Care Medicine

Background:

  • Central Diabetes Insipidus (CDI) is a potential complication following cardiopulmonary arrest (CPA) and anoxic brain injury.
  • Early recognition and management of CDI are crucial in post-CPA patients.

Observation:

  • A case of transient CDI developed four days after CPA.
  • The patient presented with polyuria and severe hypernatremia (199 mM).

Findings:

  • The hypernatremia was exacerbated by the administration of isotonic saline for fluid replacement.
  • This suggests a critical interaction between CDI pathophysiology and fluid management strategies.

Implications:

  • Highlights the importance of monitoring for CDI in patients with anoxic brain injury.
  • Underscores the need for careful fluid management in patients with CDI to avoid exacerbating hypernatremia.

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