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HISTAMINE RELEASE AND CHANDONIUM IODIDE

Y V Suri1, B B Nayak2, M Jaiprakash3

  • 1Senior Adviser (Anaesthesiology), Command Hospital Western Command, Chandimandir.

Medical Journal, Armed Forces India
|August 4, 2017
PubMed

Insights

Chandonium iodide is a safe neuromuscular blocking agent, unlike d-tubocurarine, which showed significant histamine release in animal and human studies. This study compared the histamine releasing activity of both drugs.

Area of Science:

  • Pharmacology
  • Anesthesiology
  • Clinical Toxicology

Background:

  • Neuromuscular blocking agents are crucial in anesthesia.
  • Histamine release is a potential side effect of some neuromuscular blocking agents.
  • Chandonium iodide and d-tubocurarine are neuromuscular blocking agents with different safety profiles.

Purpose of the Study:

  • To compare the histamine releasing activity of chandonium iodide and d-tubocurarine.
  • To evaluate the safety of chandonium iodide as a neuromuscular blocking agent.

Main Methods:

  • In vitro studies using guinea pig ileum.
  • In vivo studies using guinea pig peritoneum.
  • Intradermal testing in human volunteers at dilutions of 1:1,000 and 1:10,000.

Main Results:

  • d-tubocurarine demonstrated significant histamine releasing activity in vivo and a high incidence of positive intradermal reactions in humans (53.5% and 13.5%).
  • Chandonium iodide exhibited no histamine releasing activity in either animal models or human subjects.
  • Chandonium iodide was found to be a safe neuromuscular blocking agent.

Conclusions:

  • Chandonium iodide is a safe neuromuscular blocking agent with minimal risk of histamine release.
  • d-tubocurarine possesses significant histamine releasing properties, necessitating caution during clinical use.

Keywords:
Chandonium iodideHistamine releasing activityNeuromuscular blocking agent

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