Related Experiment Video

Updated: Aug 8, 2026

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
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Cerebellar Involvement in an Immunocompetent Patient Presenting with Progressive Multifocal Leukoencephalopathy

Rafael Garcia-Carretero1, Blanca San Jose Montano2

  • 1Department of Internal Medicine, Mostoles University Hospital, Madrid, Spain.

Case Reports in Neurological Medicine
|September 16, 2017
PubMed

Insights

Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease. This case highlights a PML presentation in an 83-year-old immunocompetent male with severe cerebellar symptoms, despite no identifiable immunosuppression.

Area of Science:

  • Neurology
  • Virology
  • Immunology

Background:

  • Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease.
  • PML is typically caused by JC virus reactivation in immunosuppressed individuals.
  • Rare cases of PML in immunocompetent patients without identifiable immunodeficiency have been reported.

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