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Role of LFA-1 and ICAM-1 in Cancer

Manuel Reina1,2, Enric Espel3,4

  • 1Department of Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, Diagonal 643, 08028 Barcelona, Spain. mreina@ub.edu.

Cancers
|November 4, 2017
PubMed

Insights

This review explores how lymphocyte function-associated antigen-1 (LFA-1) and its ligand ICAM-1 impact cancer by mediating leukocyte-tumor interactions. It also examines LFA-1

Area of Science:

  • Immunology and Cancer Biology
  • Cellular Adhesion Molecules
  • Leukocyte-Tumor Interactions

Background:

  • Lymphocyte function-associated antigen-1 (LFA-1), also known as CD11a/CD18, is an integrin exclusively expressed on leukocytes.
  • LFA-1 plays a crucial role in immune cell trafficking and interactions.
  • Its primary ligand, ICAM-1 (CD54), is involved in various cellular processes, including immune responses and cancer progression.

Purpose of the Study:

  • To review the multifaceted roles of LFA-1 and ICAM-1 in cancer.
  • To elucidate how LFA-1 mediates leukocyte interactions with tumor cells.
  • To discuss the implications of LFA-1 in B-cell chronic lymphocytic leukemia and exosome-mediated tumor metastasis.

Main Methods:

  • Comprehensive literature review of studies investigating LFA-1, ICAM-1, and cancer.
  • Analysis of research focusing on lymphocyte and myeloid cell functions in tumor microenvironments.
  • Examination of data related to LFA-1's role in specific hematological malignancies and metastatic processes.

Main Results:

  • LFA-1 mediates critical interactions between leukocytes and tumor cells, influencing immune surveillance and evasion.
  • ICAM-1 contributes to tumor dynamics, with some functions independent of LFA-1 binding.
  • Exosomes expressing LFA-1 are implicated in promoting tumor growth and metastasis.

Conclusions:

  • LFA-1 and ICAM-1 are significant players in cancer biology, affecting immune cell behavior and tumor progression.
  • Targeting LFA-1-ICAM-1 interactions presents potential therapeutic strategies for various cancers.
  • Further research into LFA-1's role in leukemia and exosome-mediated metastasis is warranted.

Keywords:
cancer metastasischronic lymphocytic leukemiaexosomestumor microenvironment

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