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[Clinical problems in medical mycology: Problem number 51]

Mercedes Romero1, Fernando Messina1, Emmanuel Marín1

  • 1Unidad Micología, Hospital de Infecciosas «Dr. Francisco Javier Muñiz», Buenos Aires, Argentina.

Revista Iberoamericana De Micologia
|November 25, 2017
PubMed

Insights

A woman with Cryptococcus gattii infection showed a neck lesion and lung infiltrate. Treatment with itraconazole led to an excellent clinical response, highlighting effective antifungal therapy.

Area of Science:

  • Medical Mycology
  • Infectious Diseases

Background:

  • Cryptococcus gattii is an emerging fungal pathogen causing cryptococcosis.
  • Immunocompetent individuals can be affected by Cryptococcus gattii infections.

Observation:

  • A 48-year-old immunocompetent woman presented with a neck nodule and pulmonary infiltrate.
  • The pulmonary infiltrate resolved spontaneously.
  • Histopathology revealed encapsulated yeasts consistent with Cryptococcus.

Findings:

  • Cryptococcus gattii (VGII) was isolated from a nodular lesion.
  • Serum cryptococcal antigen was positive (1:100).
  • Initial fluconazole treatment showed partial improvement, but subsequent itraconazole therapy resulted in an excellent clinical response.

Implications:

  • This case highlights the importance of considering Cryptococcus gattii in immunocompetent patients with disseminated disease.
  • Effective antifungal treatment, such as itraconazole, is crucial for managing Cryptococcus gattii infections.
  • Early diagnosis and appropriate antifungal selection are key for favorable outcomes in cryptococcosis.

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