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Laparoscopic Extracorporeal Knot-Tying for Uterine Vessel Occlusion during Hysterectomy with Cervical Cerclage in Large Uteri
Published on: September 12, 2025
In-Bag Morcellation as a Routine for Laparoscopic Hysterectomy
Stefan Rimbach1,2, Miriam Schempershofe1,2
1Department of Gynecology and Obstetrics, Agatharied Hospital, Norbert-Kerkel-Platz, 83734 Hausham, Germany.
Insights
Routine use of in-bag morcellation during laparoscopic hysterectomy effectively contained tissue, preventing spread of unsuspected malignancy. This safe containment technique demonstrated a high technical success rate in the study cohort.
Area of Science:
- Gynecology
- Surgical Oncology
- Minimally Invasive Surgery
Background:
- Laparoscopic hysterectomy carries a risk of disseminating unsuspected malignant cells through tissue morcellation.
- Contained morcellation techniques aim to mitigate this risk by enclosing the specimen within a bag during the procedure.
Purpose of the Study:
- To evaluate the safety and efficacy of routine in-bag morcellation during laparoscopic hysterectomy.
- To assess the technical success rate and potential for cell spread with the More-Cell-Safe system.
Main Methods:
- A consecutive cohort of 49 patients undergoing laparoscopic hysterectomy utilized routine in-bag morcellation.
- The More-Cell-Safe containment system was employed, and outcomes including operative time, specimen weight, and residual tissue were recorded.
- Peritoneal washings were analyzed for malignant or smooth muscle cells post-morcellation.
Main Results:
- No cases of unsuspected malignancy were identified.
- The technical success rate for contained morcellation was 93.9%.
- Morcellation time correlated with uterine volume and specimen weight but not BMI; peritoneal washings were negative for malignant cells.
Conclusions:
- Routine in-bag morcellation is a safe and effective method for laparoscopic hysterectomy, significantly reducing the risk of spreading unsuspected malignant cells.
- The More-Cell-Safe system provides reliable containment, with a high success rate and no evidence of cell dissemination in this cohort.
Abstract:
Tissue morcellation during laparoscopic hysterectomy carries the risk of spreading cells from unsuspected malignancy. Contained morcellation inside a bag is supposed to minimize this risk. The present study evaluated routine use of in-bag morcellation during laparoscopic hysterectomy in a consecutive patient cohort (n = 49). The system used was More-Cell-Safe (A.M.I. Austria). Median age was 47 (35 to 76) years and BMI 25.1 (18.8 to 39.8). Indications for hysterectomy were fibroids (71.4%), adenomyosis (16.3%), prolapse (8.2%), and bleeding disorders (4.1%). 48 (98%) patients underwent supracervical hysterectomy and 1 (2%) underwent total hysterectomy. No unsuspected malignancy occurred. Median weight of extirpated tissue was 195 g (18 to 1110). Residual tissue and/or fluid in the bag amounted to 29 g (0 to 291). Median overall duration of surgeries was 100.5 min, and median time associated with the use of the bag was 10 min (5 to 28), significantly correlated with uterine volume (p = 0.0094) and specimen weight (p = 0.0002), but not with patient's BMI (p = 0.6970). Technical success rate for contained morcellation was 93.9%. Peritoneal washings after contained morcellation were all negative for malignant or smooth muscle cells.
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