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Updated: Feb 13, 2026

Isolation, Identification, and Purification of Murine Thymic Epithelial Cells
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In situ evidence of cellular senescence in Thymic Epithelial Cells (TECs) during human thymic involution

Alexandra Barbouti1, Konstantinos Evangelou2, Ioannis S Pateras3

  • 1Department of Anatomy-Histology-Embryology, Medical School, University of Ioannina, Ioannina, Greece.

Mechanisms of Ageing and Development
|March 1, 2018
PubMed

Insights

Cellular senescence, a key aging process, is newly found to occur during human thymic involution. This discovery offers new insights into the aging immune system and thymus function.

Area of Science:

  • Immunology
  • Cellular Biology
  • Gerontology

Background:

  • Cellular senescence is an age-related process linked to damage and stress.
  • Thymic involution, characterized by age-related changes, affects the immune system's central organ.
  • Mechanisms driving thymic involution remain incompletely understood.

Purpose of the Study:

  • To investigate the potential role of cellular senescence in human thymic involution.
  • To provide novel insights into the histophysiology of the aging thymus.

Main Methods:

  • Utilized SenTraGor™, a novel chemical compound for in situ analysis.
  • Applied the compound to archival human thymus tissue samples.

Main Results:

  • Demonstrated the presence of cellular senescence within the human thymus during involution.
  • Provided the first in situ evidence of senescence in this context.

Conclusions:

  • Cellular senescence is implicated in the process of human thymic involution.
  • SenTraGor™ is effective for studying senescence in archival tissues, advancing thymus research.

Keywords:
Cellular senescenceLipofuscinSenTraGor(TM)Thymic involution

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