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Updated: Feb 13, 2026

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
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Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

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Possible Interrelationship of Inflammatory Cells in Dry Type Cutaneous Leishmaniasis

Elham Taheri1, Shahriar Dabiri1, Manzumeh Shamsi Meymandi1

  • 1Dept. of Pathology, Pathology and Stem cell Research Center, Afzalipour Medical School, Kerman.

Iranian Journal of Pathology
|March 9, 2018
PubMed

Insights

This study investigated immune cell interactions in cutaneous leishmaniasis (CL). Macrophages and dendritic cells (DCs) showed parallel increases in acute CL, suggesting potential therapeutic targets for leishmaniasis.

Area of Science:

  • Immunology
  • Dermatology
  • Parasitology

Background:

  • Cutaneous leishmaniasis (CL) involves complex host immune cell interactions affecting disease outcome.
  • Understanding these interactions is crucial for developing effective treatments.

Purpose of the Study:

  • To characterize the number, distribution, co-localization, and interrelation of four inflammatory cell types in different clinical forms of dry-type CL.
  • To explore the roles of macrophages and dendritic cells (DCs) in CL pathogenesis.

Main Methods:

  • Studied 39 CL cases classified as acute (< 2 years), chronic (> 2 years), or lupoid leishmaniasis.
  • Employed hematoxylin and eosin (H&E) staining and immunohistochemistry for CD4, CD8, CD68 (macrophages), and CD1a (dendritic cells).

Main Results:

  • In acute CL, CD68+ macrophages and CD1a+ epidermal dendritic cells (DCs) populations increased in parallel.
  • In lupoid CL, CD1a+ epidermal DCs correlated with CD1a+ dermal DCs, with parallel increases observed.

Conclusions:

  • Findings provide a baseline for targeted therapies focusing on macrophage and DC synergy against Leishmania.
  • Results suggest potential for individualized vaccine strategies based on macrophage-DC interactions in CL.
Abstract

Keywords:
Cutaneous LeishmaniasisDendritic CellsMacrophages

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